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Contraindications
Nephrolithiasis, nephrocalcinosis, hypervitaminosis D, hypercalcaemia, hypercalciuria; diseases leading to hypercalcaemia or hypercalciuria (e.g. bone metastases or other malignant bone diseases, myeloma, primary hyperparathyroidism). Severe renal failure and impairment.
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Special Precautions
Patient with achlorhydria, hypoparathyroidism; risk factor for hypercalcaemia (e.g. sarcoidosis), history of kidney stones, high tendency to calculus formation. Immobilised patients with osteoporosis. Mild to moderate renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor serum Ca levels and renal function (e.g. serum creatinine).
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Adverse Reactions
Significant: Hypercalcaemia, Milk-alkali syndrome, constipation, bloating, flatulence.
Gastrointestinal disorders: Nausea, abdominal pain, diarrhoea.
Immune system disorders: Hypersensitivity reactions.
Renal and urinary disorders: Hypercalciuria.
Skin and subcutaneous tissue disorders: Rarely, rash, pruritus, urticaria.
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Drug Interactions
May enhance the arrhythmogenic effects of cardiac glycosides.
Calcium carbonate: Increased risk of hypercalcaemia with thiazide diuretics. May decrease the gastrointestinal absorption of bisphosphonates, Na fluoride, quinolones, tetracyclines, levothyroxine, Fe, zinc and strontium. Ca absorption may be reduced by systemic corticosteroids.
Vitamin D3: Decreased effects with phenytoin, barbiturates, rifampicin, glucocorticosteroids. May reduce gastrointestinal absorption with colestyramine or paraffin oil.
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CIMS Class
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ATC Classification
A12AA04 - calcium carbonate ; Belongs to the class of calcium-containing preparations. Used as dietary supplements.
A02AC01 - calcium carbonate ; Belongs to the class of calcium-containing antacids. A11CC05 - colecalciferol ; Belongs to the class of vitamin D and analogues. Used as dietary supplements. |
